Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression

Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression

We report two cases of recurrence of primary biliary cirrhosis (PBC) in the transplanted liver whilst maintained on a FK506-based immunosuppressive regime, the first to be described. One patient experienced symptoms in association with the development of cholestasis. In both there was a persistence...

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Veröffentlicht in:Journal of hepatology 1993-03, Vol.17 (3), p.284-287
Hauptverfasser: Wong, Philip Y.N., Portmann, Bernard, o'Grady, John G., Devlin, John J., Hegarty, John E., Tan, K.-C., Williams, Roger
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Cholestasis
Cholestasis - etiology
Cholestasis - pathology
Drug toxicity and drugs side effects treatment
Female
Graft dysfunction
Humans
Liver biopsy
Liver Cirrhosis, Biliary - etiology
Liver Cirrhosis, Biliary - pathology
Liver Transplantation
Male
Medical sciences
Middle Aged
Orthotopic liver transplantation
Pharmacology. Drug treatments
Primary biliary cirrhosis
Recurrence
Tacrolimus - therapeutic use
Toxicity: digestive system
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Zusammenfassung:We report two cases of recurrence of primary biliary cirrhosis (PBC) in the transplanted liver whilst maintained on a FK506-based immunosuppressive regime, the first to be described. One patient experienced symptoms in association with the development of cholestasis. In both there was a persistence of serological markers of PBC and liver histology revealed florid bile duct destruction and a granulomatous reaction.
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(05)80206-5