Anticonvulsant activity of the γ-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol

The N-4,4-diphenyl-3-butenyl derivative of the glial selective γ-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Fol...

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Veröffentlicht in:	European journal of pharmacology 1993-05, Vol.236 (1), p.147-149
Hauptverfasser:	White, H.Steve, Hunt, Jason, Wolf, Harold H., Swinyard, Ewart A., Falch, Erik, Krogsgaard-Larsen, Povl, Schousboe, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Anticonvulsants - administration & dosage Anticonvulsants - pharmacology Biological and medical sciences Dose-Response Relationship, Drug Epilepsy Frings audiogenic seizure-susceptible mice GABA Antagonists GABA uptake (glial) GABA uptake inhibitors Gabaergic and benzodiazepinic system gamma-Aminobutyric Acid - metabolism Injections, Intraventricular Isoxazoles - pharmacology Medical sciences Mice Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Seizures - prevention & control
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Zusammenfassung:	The N-4,4-diphenyl-3-butenyl derivative of the glial selective γ-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) administration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and time-dependent manner. At the doses tested no gross behavioral effects were noted.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(93)90238-D