EFFECT OF AGE ON THE SENSITIVITY OF UPPER AIRWAY REFLEXES

We have recorded the threshold concentration of inhaled ammonia vapour required to elicit reflex glottic closure (NH3TR) in 102 healthy, nonsmoking volunteers (39 female) aged 17-96 yr in order to assess the effect of age upon upper airway reflex sensitivity. A single measurement of sensitivity was...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1993-05, Vol.70 (5), p.574-575
Hauptverfasser:	ERSKINE, R.J., MURPHY, P.J., LANGTON, J.A., SMITH, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age factors Aged Aged, 80 and over Aging - physiology Air breathing Airway: reflex sensitivity Ammonia - pharmacology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Glottis - physiology Humans Larynx - physiology Male Middle Aged Reflex - drug effects Reflex - physiology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system
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Zusammenfassung:	We have recorded the threshold concentration of inhaled ammonia vapour required to elicit reflex glottic closure (NH3TR) in 102 healthy, nonsmoking volunteers (39 female) aged 17-96 yr in order to assess the effect of age upon upper airway reflex sensitivity. A single measurement of sensitivity was made in each subject using a system delivering small concentrations of ammonia vapour for single intermittent breaths to the upper airway and recording glottic closure using an inspiratory pneumotachograph. We found a strong positive correlation between age and NH3TR, indicating a decrease in upper airway reflex sensitivity with increasing age. (Br. J. Anaesth. 1993; 70: 574–575)
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/70.5.574