Steroid receptors in intracranial tumors
Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas containe...
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| Veröffentlicht in: | Clinical neuropharmacology 1984-01, Vol.7 (4), p.347-350 |
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| creator | Brentani, M M Lopes, M T Martins, V R Plese, J P |
| description | Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas contained positive (greater than or equal to 10 fmol/mg protein) but low ER levels. On the other hand, positive PR, GR, and AR levels were detectable in 100% (six) of the meningiomas. PR was present in 50% (six), AR in 42% (five), and GR in 58% (seven) of the gliomas. PR, GR, and AR values were statistically higher in meningiomas than in neuroepithelial tumors. |
| doi_str_mv | 10.1097/00002826-198412000-00013 |
| format | Article |
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| ispartof | Clinical neuropharmacology, 1984-01, Vol.7 (4), p.347-350 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Brain Neoplasms - metabolism Child Child, Preschool Female Glioma - metabolism Humans Kinetics Male Meningeal Neoplasms - metabolism Meningioma - metabolism Middle Aged Receptors, Androgen - metabolism Receptors, Estrogen - metabolism Receptors, Glucocorticoid - metabolism Receptors, Progesterone - metabolism Receptors, Steroid - metabolism |
| title | Steroid receptors in intracranial tumors |
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