Steroid receptors in intracranial tumors

Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas containe...

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Veröffentlicht in:	Clinical neuropharmacology 1984-01, Vol.7 (4), p.347-350
Hauptverfasser:	Brentani, M M, Lopes, M T, Martins, V R, Plese, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Brain Neoplasms - metabolism Child Child, Preschool Female Glioma - metabolism Humans Kinetics Male Meningeal Neoplasms - metabolism Meningioma - metabolism Middle Aged Receptors, Androgen - metabolism Receptors, Estrogen - metabolism Receptors, Glucocorticoid - metabolism Receptors, Progesterone - metabolism Receptors, Steroid - metabolism
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Zusammenfassung:	Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas contained positive (greater than or equal to 10 fmol/mg protein) but low ER levels. On the other hand, positive PR, GR, and AR levels were detectable in 100% (six) of the meningiomas. PR was present in 50% (six), AR in 42% (five), and GR in 58% (seven) of the gliomas. PR, GR, and AR values were statistically higher in meningiomas than in neuroepithelial tumors.
ISSN:	0362-5664
DOI:	10.1097/00002826-198412000-00013