Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro

The addition of ingestable particles (opsonized erythrocytes or latex beads) or a phorbol ester activates monocytes--derived human macrophages (MDHM) cultured in vitro, and markedly reduces virion release from HIV-infected MDHM as well as their ability to transmit the infection to cocultured lymphoi...

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Veröffentlicht in:	Archives of virology 1993-01, Vol.130 (3-4), p.463-469
Hauptverfasser:	PIEDIMONTE, G, MONTRONI, M, SILVESTRI, G, SILVOTTI, L, DONATINI, A, ROSSI, L, BORGHETTI, A. F, MAGNANI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Fundamental and applied biological sciences. Psychology HIV-1 - immunology HIV-1 - physiology human immunodeficiency virus 1 Humans In Vitro Techniques Macrophage Activation - physiology Macrophages - immunology Macrophages - microbiology Microbiology Monocytes - immunology Monocytes - microbiology Phagocytosis - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology Virus Replication - immunology
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Beschreibung
Zusammenfassung:	The addition of ingestable particles (opsonized erythrocytes or latex beads) or a phorbol ester activates monocytes--derived human macrophages (MDHM) cultured in vitro, and markedly reduces virion release from HIV-infected MDHM as well as their ability to transmit the infection to cocultured lymphoid CD4-positive CEM cells.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/BF01309674