Comparison of the satiating potencies of cholecystokinin-33 and cholecystokinin-8

We investigated the satiating potency of CCK-33 and of CCK-8 administered IP to rats prior to a 30-min food intake test using a high-carbohydrate liquid diet. CCK-33 and CCK-8 produced dose-related inhibitions of intake. The ID 50s and the slopes of the dose-response functions of the two peptides we...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1993-05, Vol.45 (1), p.85-87
Hauptverfasser:	Melville, L.D., Smith, G.P., Gibbs, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cholecystokinin - pharmacology Dietary Carbohydrates - pharmacology Dose-Response Relationship, Drug Food intake General and cellular metabolism. Vitamins Male Medical sciences Peptides Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Satiety Satiety Response - drug effects Sincalide - pharmacology Swine
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Zusammenfassung:	We investigated the satiating potency of CCK-33 and of CCK-8 administered IP to rats prior to a 30-min food intake test using a high-carbohydrate liquid diet. CCK-33 and CCK-8 produced dose-related inhibitions of intake. The ID 50s and the slopes of the dose-response functions of the two peptides were not significantly different. We conclude that CCK-33 is as potent as CCK-8 for inhibiting food intake in the rat.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(93)90090-G