Lesion-induced NADPH-diaphorase reactivity in neocortical pyramidal neurones

Pyramidal neurones of the rat neocortex do not normally express NADPH-diaphorase reactivity. However, after stab lesions which extended through the entire depth of the neocortex, strong NADPH-diaphorase reactivity was observed in pyramidal neurones at 7 and 14 days post-lesion. At 3 and 21 days post...

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Veröffentlicht in:Neuroreport 1993-05, Vol.4 (5), p.487-490
Hauptverfasser: Kitchener, P D, Van der Zee, C E. E. M, Diamond, J
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Sprache:eng
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Zusammenfassung:Pyramidal neurones of the rat neocortex do not normally express NADPH-diaphorase reactivity. However, after stab lesions which extended through the entire depth of the neocortex, strong NADPH-diaphorase reactivity was observed in pyramidal neurones at 7 and 14 days post-lesion. At 3 and 21 days post-lesion fewer and less reactive pyramidal neurones were observed, and no reactive pyramidal neurones were seen at 2 and 26 days postlesion. The great majority of reactive pyramidal neurones were in layers V and VI and most were situated medial to the lesion. The induction of NADPH-diaphorase implies that the capability to synthesize nitric oxide may be a component of the pyramidal neuronesʼ response to traumatic injury.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199305000-00006