Recombinant antibodies possessing novel effector functions

The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moie...

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Veröffentlicht in:	Nature (London) 1984-01, Vol.312 (5995), p.604-608
Hauptverfasser:	Neuberger, Michael S, Williams, Gareth T, Fox, Robert O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies Antibodies, immunoglobulins Antibodies, Monoclonal - genetics Antigen-Antibody Complex Biological and medical sciences Biotechnology Cell Line Chimera Cloning, Molecular Disulfides DNA DNA Restriction Enzymes Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Haptens Health. Pharmaceutical industry Hybridomas - immunology Immunoglobulin Fab Fragments - genetics immunoglobulins Industrial applications and implications. Economical aspects lymphocytes Lymphocytes - immunology Mice Micrococcal Nuclease - metabolism Molecular immunology Monoclonal antibodies Oncogenes Plasmacytoma - immunology Plasmids Production of active biomolecules Staphylococcus aureus - enzymology Transfection
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Beschreibung
Zusammenfassung:	The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/312604a0