Immunohistochemical localization of pregnancy-associated plasma protein a in decidua and trophoblast: Comparison with human chorionic gonadotrophin and fibrin

In an immunoperoxidase study, pregnancy-associated placental protein A (PAPP-A) was localized to the cytoplasm of decidual stromal cells, the villous syncytiotrophoblast and on the surface of placental trophoblast. A decidual and a trophoblastic origin is suggested for PAPP-A, and its presence on th...

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Veröffentlicht in:	Placenta (Eastbourne) 1984-05, Vol.5 (3), p.227-235
Hauptverfasser:	Schindler, A.-M., Bordignon, P., Bischof, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chorionic Gonadotropin - analysis Chorionic Gonadotropin, beta Subunit, Human Decidua - analysis Female Fibrin - analysis Fibrinogen - analysis Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Peptide Fragments - analysis Pregnancy Pregnancy Proteins - analysis Pregnancy Trimester, First Pregnancy Trimester, Third Pregnancy-Associated Plasma Protein-A - analysis Pregnancy. Parturition. Lactation Trophoblasts - analysis Vertebrates: reproduction
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Zusammenfassung:	In an immunoperoxidase study, pregnancy-associated placental protein A (PAPP-A) was localized to the cytoplasm of decidual stromal cells, the villous syncytiotrophoblast and on the surface of placental trophoblast. A decidual and a trophoblastic origin is suggested for PAPP-A, and its presence on the surface of the syncytiotrophoblast is interpreted as a possible immunoprotective layer.
ISSN:	0143-4004 1532-3102
DOI:	10.1016/S0143-4004(84)80032-6