Sequence and expression of transcripts of the human T-cell receptor β- chain genes
T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β -chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V , J and one of the two C region sequences, but does not always contain D sequences. A 1.0 -kb mRNA, found mainly in...
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| Veröffentlicht in: | Nature (London) 1984-01, Vol.312 (5994), p.521-524 |
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| container_issue | 5994 |
| container_start_page | 521 |
| container_title | Nature (London) |
| container_volume | 312 |
| creator | Yoshikai, Yasunobu Anatoniou, Demetri Clark, Stephen P. Yanagi, Yusuke Sangster, Robert Van den Elsen, Peter Terhorst, Cox Mak, Tak. W. |
| description | T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor
β
-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains
V
,
J
and one of the two
C
region sequences, but does not always contain
D
sequences. A
1.0
-kb mRNA, found mainly in immature T cells, does not contain
V
sequences and can result from transcription that initiates upstream from an unrearranged
J
element. |
| doi_str_mv | 10.1038/312521a0 |
| format | Article |
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β
-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains
V
,
J
and one of the two
C
region sequences, but does not always contain
D
sequences. A
1.0
-kb mRNA, found mainly in immature T cells, does not contain
V
sequences and can result from transcription that initiates upstream from an unrearranged
J
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β
-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains
V
,
J
and one of the two
C
region sequences, but does not always contain
D
sequences. A
1.0
-kb mRNA, found mainly in immature T cells, does not contain
V
sequences and can result from transcription that initiates upstream from an unrearranged
J
element.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell interactions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genes. Genome</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Macromolecular Substances</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>multidisciplinary</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Recombination, Genetic</subject><subject>RNA, Messenger - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>T-Lymphocytes - physiology</subject><subject>Transcription, Genetic</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUhgdRaq2CLyDMQkQX0blPspTiDQouWtdhMjlpU9JJnElAX8sH8ZlMbXTjwtVh-D_-c-ZD6JSSa0p4fMMpk4wasofGVGgVCRXrfTQmhMURibk6REchrAkhkmoxQiPFuWBcj9F8Dq8dOAvYuBzDW-MhhLJ2uC5w640L1pdNG76fK8CrbmMcXkQWqgp7sNC0tcefHxG2K1M6vAQH4RgdFKYKcDLMCXq5v1tMH6PZ88PT9HYWWa5ZG6nCAGRMCSkKSTiNc84lBZEZooXMEmk0Z0wLZkFBImNiM8iTnGaJJirPGZ-gi11v4-v-E6FNN2XYXmYc1F1ItdSx4Ir-C1IhlaB823i5A62vQ_BQpI0vN8a_p5SkW9Hpj-gePRs6u2wD-S84mO3z8yE3wZqq6F3aMvxiCaH9eaLHrnZY6BO3BJ-u6867XtvflV8sjpFC</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Yoshikai, Yasunobu</creator><creator>Anatoniou, Demetri</creator><creator>Clark, Stephen P.</creator><creator>Yanagi, Yusuke</creator><creator>Sangster, Robert</creator><creator>Van den Elsen, Peter</creator><creator>Terhorst, Cox</creator><creator>Mak, Tak. 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Genome</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Macromolecular Substances</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>multidisciplinary</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Recombination, Genetic</topic><topic>RNA, Messenger - genetics</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>T-Lymphocytes - physiology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikai, Yasunobu</creatorcontrib><creatorcontrib>Anatoniou, Demetri</creatorcontrib><creatorcontrib>Clark, Stephen P.</creatorcontrib><creatorcontrib>Yanagi, Yusuke</creatorcontrib><creatorcontrib>Sangster, Robert</creatorcontrib><creatorcontrib>Van den Elsen, Peter</creatorcontrib><creatorcontrib>Terhorst, Cox</creatorcontrib><creatorcontrib>Mak, Tak. 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W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence and expression of transcripts of the human T-cell receptor β- chain genes</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>312</volume><issue>5994</issue><spage>521</spage><epage>524</epage><pages>521-524</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor
β
-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains
V
,
J
and one of the two
C
region sequences, but does not always contain
D
sequences. A
1.0
-kb mRNA, found mainly in immature T cells, does not contain
V
sequences and can result from transcription that initiates upstream from an unrearranged
J
element.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6334237</pmid><doi>10.1038/312521a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1984-01, Vol.312 (5994), p.521-524 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences Cell interactions Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Genes Genes. Genome Humanities and Social Sciences Humans Immunobiology Macromolecular Substances Molecular and cellular biology Molecular genetics multidisciplinary Receptors, Antigen, T-Cell - genetics Recombination, Genetic RNA, Messenger - genetics Science Science (multidisciplinary) T-Lymphocytes - physiology Transcription, Genetic |
| title | Sequence and expression of transcripts of the human T-cell receptor β- chain genes |
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