Sequence and expression of transcripts of the human T-cell receptor β- chain genes

T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β -chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V , J and one of the two C region sequences, but does not always contain D sequences. A 1.0 -kb mRNA, found mainly in...

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Veröffentlicht in:	Nature (London) 1984-01, Vol.312 (5994), p.521-524
Hauptverfasser:	Yoshikai, Yasunobu, Anatoniou, Demetri, Clark, Stephen P., Yanagi, Yusuke, Sangster, Robert, Van den Elsen, Peter, Terhorst, Cox, Mak, Tak. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences Cell interactions Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Genes Genes. Genome Humanities and Social Sciences Humans Immunobiology Macromolecular Substances Molecular and cellular biology Molecular genetics multidisciplinary Receptors, Antigen, T-Cell - genetics Recombination, Genetic RNA, Messenger - genetics Science Science (multidisciplinary) T-Lymphocytes - physiology Transcription, Genetic
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Beschreibung
Zusammenfassung:	T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β -chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V , J and one of the two C region sequences, but does not always contain D sequences. A 1.0 -kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/312521a0