Molecular cloning of a cDNA encoding human antihaemophilic factor

A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats an...

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Veröffentlicht in:	Nature (London) 1984, Vol.312 (5992), p.342-347
Hauptverfasser:	Toole, John J, Knopf, John L, Wozney, John M, Sultzman, Lisa A, Buecker, Janet L, Pittman, Debra D, Kaufman, Randal J, Brown, Eugene, Shoemaker, Charles, Orr, Elizabeth C, Amphlett, Godfrey W, Foster, W. Barry, Coe, Mary Lou, Knutson, Gaylord J, Fass, David N, Hewick, Rodney M
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid sequence Animals Antigens - genetics Biological and medical sciences Biotechnology Blood coagulation. Blood cells cDNA Cloning, Molecular coagulation factor VIII Coagulation factors DNA - genetics Factor VIII - genetics Factor VIII - immunology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects man Molecular and cellular biology Molecular Weight mRNA nucleotide sequence Other active biomolecules Production of active biomolecules RNA, Messenger - genetics Swine
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Beschreibung
Zusammenfassung:	A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/312342a0