Structure of human factor VIII

Structure of human factor VIII

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the th...

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Veröffentlicht in:Nature (London) 1984-01, Vol.312 (5992), p.337-342
Hauptverfasser: Vehar, Gordon A, Keyt, Bruce, Eaton, Dan, Rodriguez, Henry, O'Brien, Donogh P, Rotblat, Frances, Oppermann, Herman, Keck, Rodney, Wood, William I, Harkins, Richard N, Tuddenham, Edward G. D, Lawn, Richard M, Capon, Daniel J
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Ceruloplasmin
coagulation factor VIII
Factor VIII
Humanities and Social Sciences
Humans
man
multidisciplinary
nucleotide sequence
Peptide Fragments - analysis
Protein Conformation
Protein Precursors
Science
Science (multidisciplinary)
Thrombin - metabolism
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Beschreibung
Zusammenfassung:The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.
ISSN:0028-0836
1476-4687
DOI:10.1038/312337a0