Cytoplasmic and Nuclear STAT3 in GH-Stimulated Fibroblasts of Children with Idiopathic Short Stature

Cytoplasmic and Nuclear STAT3 in GH-Stimulated Fibroblasts of Children with Idiopathic Short Stature

Background: STAT5, which plays an important role in GH signal transduction, has been studied extensively in children with growth retardation, but there is scarce information regarding STAT3. Aim: We determined total and phosphorylated STAT3 after GH stimulation in fibroblasts from children with idio...

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Veröffentlicht in:Hormone research in paediatrics 2010-01, Vol.74 (4), p.251-258
Hauptverfasser: Martínez Pinto, Jonathan, Salazar, Teresa, Ocaranza, Paula, Fuentes, Ariel, Román, Rossana, Cassorla, Fernando
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Cell Nucleus - metabolism
Cells, Cultured
Child
Child, Preschool
Cytoplasm - metabolism
Down-Regulation
Female
Fibroblasts - metabolism
Growth Disorders - metabolism
Human Growth Hormone - metabolism
Humans
Male
Original Paper
Phosphorylation
Protein Transport
Recombinant Proteins
Signal Transduction
Skin - cytology
Skin - metabolism
STAT3 Transcription Factor - metabolism
Time Factors
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Zusammenfassung:Background: STAT5, which plays an important role in GH signal transduction, has been studied extensively in children with growth retardation, but there is scarce information regarding STAT3. Aim: We determined total and phosphorylated STAT3 after GH stimulation in fibroblasts from children with idiopathic short stature (ISS) and control children with normal stature. Subjects and Methods: We studied 15 prepubertal children (age 7.6 ± 0.4 years) with short stature (height –2.8 ± 0.2 SDS), decreased growth velocity (10 ng/ml to the clonidine stimulation test and decreased serum IGF-I concentrations (
ISSN:1663-2818
1663-2826
DOI:10.1159/000313415