Strong Detrimental Effect of a Minute Enantiomeric Impurity of a Chiral Selector on the Enantioselectivity Factor
Without a trace? The higher the enantioselectivity of a chiral selector, the more it is sensitive to enantiomeric impurities. Therefore, the enantiomeric purity of a chiral selector affects the enantioseparation factor α (see picture).
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2010-10, Vol.49 (42), p.7742-7744 |
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| container_issue | 42 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 49 |
| creator | Levkin, Pavel A Maier, Norbert M Schurig, Volker Lindner, Wolfgang |
| description | Without a trace? The higher the enantioselectivity of a chiral selector, the more it is sensitive to enantiomeric impurities. Therefore, the enantiomeric purity of a chiral selector affects the enantioseparation factor α (see picture). |
| doi_str_mv | 10.1002/anie.201002215 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Amino Acids - isolation & purification chiral chromatography chiral selectors Chromatography, High Pressure Liquid Dinitrobenzenes - isolation & purification enantiomer separation enantioselectivity liquid chromatography Molecular Structure Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Quinidine - chemistry Quinine - chemistry Stereoisomerism |
| title | Strong Detrimental Effect of a Minute Enantiomeric Impurity of a Chiral Selector on the Enantioselectivity Factor |
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