Strong Detrimental Effect of a Minute Enantiomeric Impurity of a Chiral Selector on the Enantioselectivity Factor

Without a trace? The higher the enantioselectivity of a chiral selector, the more it is sensitive to enantiomeric impurities. Therefore, the enantiomeric purity of a chiral selector affects the enantioseparation factor α (see picture).

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-10, Vol.49 (42), p.7742-7744
Hauptverfasser:	Levkin, Pavel A, Maier, Norbert M, Schurig, Volker, Lindner, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - isolation & purification chiral chromatography chiral selectors Chromatography, High Pressure Liquid Dinitrobenzenes - isolation & purification enantiomer separation enantioselectivity liquid chromatography Molecular Structure Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Quinidine - chemistry Quinine - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Without a trace? The higher the enantioselectivity of a chiral selector, the more it is sensitive to enantiomeric impurities. Therefore, the enantiomeric purity of a chiral selector affects the enantioseparation factor α (see picture).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201002215