Cloxacillin absorption and disposition in cystic fibrosis

Cloxacillin absorption and disposition in cystic fibrosis

Because of reports of lowered antibiotic serum concentrations in patients with cystic fibrosis (CF), a bioavailability and pharmacokinetic study of cloxacillin was conducted in 12 control and 16 patients with CF after intravenously and orally administered doses of cloxacillin 25 mg/kg. The patients...

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Veröffentlicht in:The Journal of pediatrics 1984-11, Vol.105 (5), p.829-835
Hauptverfasser: Spino, Michael, Chai, Roger P., Isles, Alan F., Thiessen, Jake J., Tesoro, Angel, Gold, Ronald, MacLeod, Stuart M.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adolescent
Adult
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological Availability
Cloxacillin - administration & dosage
Cloxacillin - blood
Cloxacillin - metabolism
Cystic Fibrosis - drug therapy
Cystic Fibrosis - metabolism
Humans
Infusions, Parenteral
Kidney - metabolism
Kinetics
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:Because of reports of lowered antibiotic serum concentrations in patients with cystic fibrosis (CF), a bioavailability and pharmacokinetic study of cloxacillin was conducted in 12 control and 16 patients with CF after intravenously and orally administered doses of cloxacillin 25 mg/kg. The patients had mild to moderate CF and were in stable condition. Significantly lower serum concentrations in CF were a result of a 78% increase in total body clearance ( P
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(84)80317-0