Laser treatment of keloids: A clinical trial and an in vitro study with Nd:YAG laser

Biochemical studies utilizing keloid fibroblast cultures revealed that Nd: YAG laser selectively suppressed collagen production by these cells. Based on these in vitro observations, eight patients with keloids were treated with Nd:YAG laser in a nondestructive manner. Results, with a 3‐year follow‐u...

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Veröffentlicht in:	Lasers in surgery and medicine 1984, Vol.4 (3), p.291-295
Hauptverfasser:	Abergel, R. Patrick, Dwyer, Richard M., Meeker, Cheryl A., Uitto, Jouni, Lask, Gary, Kelly, A. Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult bioinhibition Biological and medical sciences Cells, Cultured Clinical Trials as Topic collagen Collagen - biosynthesis Female Fibroblasts - metabolism Fibroblasts - radiation effects Follow-Up Studies Humans Infectious diseases Keloid - metabolism Keloid - surgery keloid fibroblast Laser Therapy Medical sciences Nd:YAG Neodymium Yttrium
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Beschreibung
Zusammenfassung:	Biochemical studies utilizing keloid fibroblast cultures revealed that Nd: YAG laser selectively suppressed collagen production by these cells. Based on these in vitro observations, eight patients with keloids were treated with Nd:YAG laser in a nondestructive manner. Results, with a 3‐year follow‐up, indicated flattening and softening of the lesions. Thus, the results suggest that Nd:YAG laser is an effective treatment modality for keloids, and its mechanism may involve bioinhibition of fibroblast functions.
ISSN:	0196-8092 1096-9101
DOI:	10.1002/lsm.1900040310