A Diabetic Case of Hb Riyadh with a Low HbA1c Value

A Diabetic Case of Hb Riyadh with a Low HbA1c Value

A 74-year-old male patient with diabetes mellitus and hypertension who had been treated for a long period was admitted to our hospital. Laboratory data on admission revealed high values for fasting blood sugar and fructosamine, 219 mg/dl and 389 μmol/l respectively, while the concentration of glycat...

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Veröffentlicht in:Internal Medicine 1993, Vol.32(2), pp.128-132
Hauptverfasser: MAEZAWA, Yoshihiko, YAMAUCHI, Masayoshi, NAKABAYASHI, Tomoko, TOSHIMA, Kyouichirou, IKEDA, Kiyoko, TODA, Gotaro
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomarkers
Blood Glucose - analysis
Chromatography, High Pressure Liquid
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Fructosamine
Glycated Hemoglobin A - analysis
hemoglobin Riyadh
Hemoglobins, Abnormal - analysis
Hexosamines - analysis
Humans
Isoelectric Focusing
Male
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Zusammenfassung:A 74-year-old male patient with diabetes mellitus and hypertension who had been treated for a long period was admitted to our hospital. Laboratory data on admission revealed high values for fasting blood sugar and fructosamine, 219 mg/dl and 389 μmol/l respectively, while the concentration of glycated hemoglobin (HbA1c) was low (3.0%). High performance liquid chromatography and isoelectric focusing analysis of the patient's Hb disclosed abnormal Hb with the content being 41.3%. The structural analysis indicated that this abnormal Hb was Hb Riyadh [β120 (GH3) Lys→Asn]. The low value of HbA1c despite the high blood glucose level may be attributed to this abnormal hemoglobin. (Internal Medicine 32: 128-132, 1993)
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.32.128