Immunoselection screening methods for detection of the free heavy chains

Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 μg/ml and between 3 μg and 1 mg/ml for immunoglobulins. Th...

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Veröffentlicht in:	Immunology letters 1984, Vol.8 (4), p.211-214
Hauptverfasser:	Ottó, Szaboles, Végh, Zsuzsa, Kocsis, György
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences electroimmunoassay electrosyneresis free heavy chains Fundamental and applied biological sciences. Psychology Fundamental immunology Heavy Chain Disease - immunology Heavy Chain Disease - urine Humans Immune Sera Immunoelectrophoresis - methods Immunoglobulin Heavy Chains - urine Immunoglobulin Light Chains - immunology immunoselection Molecular immunology Techniques
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Beschreibung
Zusammenfassung:	Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 μg/ml and between 3 μg and 1 mg/ml for immunoglobulins. The sensitive, relatively rapid and cheap variants of the procedure are suitable for the detection of “heavy chain diseases” and of heavy chain fragments.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/0165-2478(84)90080-4