The treatment of neonatal meningitis due to Gram-negative bacilli with ciprofloxacin: Evidence of satisfactory penetration into the cerebrospinal fluid

We describe two cases of neonatal meningitis due to Gram-negative bacilli treated successfully with ciprofloxacin. Examination of serial samples of cerebrospinal fluid indicated the effect of meningeal inflammation on penetration of this drug into the CSF.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infection 1993-05, Vol.26 (3), p.253-256
Hauptverfasser:	Green, Stephen D.R., Ilunga, François, Cheesbrough, John S., Tillotson, Glenn S., Hichens, Mark, Felmingham, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - cerebrospinal fluid Ciprofloxacin - therapeutic use Escherichia coli Infections - cerebrospinal fluid Escherichia coli Infections - drug therapy Flavobacterium - isolation & purification Gram-Negative Bacterial Infections - cerebrospinal fluid Gram-Negative Bacterial Infections - drug therapy Humans Infant, Newborn Male Medical sciences Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - drug therapy Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	We describe two cases of neonatal meningitis due to Gram-negative bacilli treated successfully with ciprofloxacin. Examination of serial samples of cerebrospinal fluid indicated the effect of meningeal inflammation on penetration of this drug into the CSF.
ISSN:	0163-4453 1532-2742
DOI:	10.1016/0163-4453(93)95291-P