Conditioned Opioid Release in Ten-Day-Old Rats

Ten-day-old rats, for whom an orange scent predicted morphine injections at 5 days of age, exhibited a marked preference for orange that was fully naltrexone reversible. Moreover, such rats, when smelling orange during a heat-escape task, exhibited a higher pain threshold than control rats. Together...

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Veröffentlicht in:	Behavioral neuroscience 1989-04, Vol.103 (2), p.423-428
Hauptverfasser:	Kehoe, Priscilla, Blass, Elliott M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animal behavior Animals Arousal - physiology Association Learning - physiology Biological and medical sciences Brain - physiology Choice Behavior Conditioning Conditioning, Classical - physiology Endogenous Opiates Endorphins - physiology Female Fundamental and applied biological sciences. Psychology Infants (Animal) Learning - physiology Learning. Memory Male Morphine - pharmacology Naltrexone - pharmacology Nociceptors - physiology Odors Pain Preferences Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Reaction Time - physiology Receptors, Opioid - physiology Smell - physiology Synaptic Transmission - drug effects
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Beschreibung
Zusammenfassung:	Ten-day-old rats, for whom an orange scent predicted morphine injections at 5 days of age, exhibited a marked preference for orange that was fully naltrexone reversible. Moreover, such rats, when smelling orange during a heat-escape task, exhibited a higher pain threshold than control rats. Together, these findings suggest that the orange odor in conditioned rats caused a release of endogenous opioids that both sustained choice behavior and modulated pain systems.
ISSN:	0735-7044 1939-0084
DOI:	10.1037/0735-7044.103.2.423