Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human cancer cell lines in vitro.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (21), p.3739-3741
Hauptverfasser: PAN, Xian-Dao, RUI HAN, SUN, Piao-Yang
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creator PAN, Xian-Dao
RUI HAN
SUN, Piao-Yang
description A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human cancer cell lines in vitro.
doi_str_mv 10.1016/j.bmcl.2003.08.012
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Camptothecin - analogs & derivatives
Camptothecin - chemical synthesis
Camptothecin - pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
General aspects
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Solvents
Structure-Activity Relationship
title Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions
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