Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human cancer cell lines in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (21), p.3739-3741
Hauptverfasser:	PAN, Xian-Dao, RUI HAN, SUN, Piao-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Camptothecin - analogs & derivatives Camptothecin - chemical synthesis Camptothecin - pharmacology Cell Line, Tumor Drug Screening Assays, Antitumor General aspects Humans Indicators and Reagents Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Solvents Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human cancer cell lines in vitro.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.08.012