A general synthesis of 1-aryl carbamoyl-2-alkyl-4-aryl substituted semicarbazides as nonbasic factor Xa inhibitors

An efficient four-step synthesis of 1-aryl-carbamoyl-2-alkyl-4-aryl-semicarbazides starting from benzophenone hydrazone is described leading to moderately active neutral factor Xa inhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (21), p.3715-3718
Hauptverfasser:	MEDERSKI, Werner W. K. R, GERMANN, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemical synthesis Alkanes - pharmacology Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Carbamates - chemical synthesis Carbamates - pharmacology Factor Xa Inhibitors Medical sciences Molecular Conformation Pharmacology. Drug treatments Semicarbazides - chemical synthesis Semicarbazides - pharmacology Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	An efficient four-step synthesis of 1-aryl-carbamoyl-2-alkyl-4-aryl-semicarbazides starting from benzophenone hydrazone is described leading to moderately active neutral factor Xa inhibitors.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.08.007