Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia
We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The...
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| Veröffentlicht in: | Human genetics 1993-05, Vol.91 (4), p.380-382 |
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| container_title | Human genetics |
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| creator | Crossen, P E Morrison, M J |
| description | We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL. |
| doi_str_mv | 10.1007/BF00217361 |
| format | Article |
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There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/BF00217361</identifier><identifier>PMID: 8099060</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Chi-Square Distribution ; chronic lymphatic leukemia ; deoxyribonuclease SstI ; Deoxyribonucleases, Type II Site-Specific ; Female ; Gene Frequency ; Genotype ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Male ; man ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Proto-Oncogenes - genetics ; restriction fragment length polymorphism</subject><ispartof>Human genetics, 1993-05, Vol.91 (4), p.380-382</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-3f1f15f0aa06737ba0734b9c526de6e4e34f8faf326f2657e8e787de4e19b863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8099060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crossen, P E</creatorcontrib><creatorcontrib>Morrison, M J</creatorcontrib><title>Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Chi-Square Distribution</subject><subject>chronic lymphatic leukemia</subject><subject>deoxyribonuclease SstI</subject><subject>Deoxyribonucleases, Type II Site-Specific</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Male</subject><subject>man</subject><subject>Middle Aged</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Proto-Oncogenes - genetics</subject><subject>restriction fragment length polymorphism</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0D1PwzAQBmALgUopLOxInhiQAuc4tpMRqhaQKjHQESlynDM15As7Qeq_J1UrGJluuEev7l5CLhncMgB197AEiJnikh2RKUt4HLEY-DGZAk8gkoqpU3IWwgcAE1ksJmSSQpaBhCl5W1T4rXssqfX4NWBjtrS1VDd0sX6NGPUYeu9M79pmFPq9xqanXVtt69Z3Gxdq6hpqNr5tnKEPkcGqohUOnxprp8_JidVVwIvDnJH1crGeP0Wrl8fn-f0qMpzxPuKWWSYsaA1ScVVoUDwpMiNiWaLEBHliU6stj6WNpVCYokpVOS5YVqSSz8j1Prbz7fhC6PPahd0lusF2CLkSSggQ2b-QSZlIUPEIb_bQ-DYEjzbvvKu13-YM8l3l-V_lI746pA5FjeUvPXTMfwCYrHsE</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Crossen, P E</creator><creator>Morrison, M J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia</title><author>Crossen, P E ; Morrison, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-3f1f15f0aa06737ba0734b9c526de6e4e34f8faf326f2657e8e787de4e19b863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Chi-Square Distribution</topic><topic>chronic lymphatic leukemia</topic><topic>deoxyribonuclease SstI</topic><topic>Deoxyribonucleases, Type II Site-Specific</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Male</topic><topic>man</topic><topic>Middle Aged</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Proto-Oncogenes - genetics</topic><topic>restriction fragment length polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crossen, P E</creatorcontrib><creatorcontrib>Morrison, M J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crossen, P E</au><au>Morrison, M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>91</volume><issue>4</issue><spage>380</spage><epage>382</epage><pages>380-382</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><abstract>We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.</abstract><cop>Germany</cop><pmid>8099060</pmid><doi>10.1007/BF00217361</doi><tpages>3</tpages></addata></record> |
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| ispartof | Human genetics, 1993-05, Vol.91 (4), p.380-382 |
| issn | 0340-6717 1432-1203 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Alleles Chi-Square Distribution chronic lymphatic leukemia deoxyribonuclease SstI Deoxyribonucleases, Type II Site-Specific Female Gene Frequency Genotype Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male man Middle Aged Polymorphism, Restriction Fragment Length Proto-Oncogenes - genetics restriction fragment length polymorphism |
| title | Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia |
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