Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia

We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The...

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Veröffentlicht in:	Human genetics 1993-05, Vol.91 (4), p.380-382
Hauptverfasser:	Crossen, P E, Morrison, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Chi-Square Distribution chronic lymphatic leukemia deoxyribonuclease SstI Deoxyribonucleases, Type II Site-Specific Female Gene Frequency Genotype Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male man Middle Aged Polymorphism, Restriction Fragment Length Proto-Oncogenes - genetics restriction fragment length polymorphism
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Zusammenfassung:	We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00217361