Microvascular damage following experimental sinus-vein thrombosis in rats

We evaluated effects of thrombosis of the superior sagittal sinus, its bridging and cortical veins (SVT) on the cerebral microvasculature in rats. Cryosections of brains ( n=7) were examined for venous infarction and microvascular basal lamina damage 3 h after SVT by immunohistochemical staining of...

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Veröffentlicht in:	Acta neuropathologica 2003-11, Vol.106 (5), p.501-505
Hauptverfasser:	VOSKO, M. R, RÖTHER, J, FRIEDL, B, BÜLTEMEIER, G, KLOSS, C. U. A, HAMANN, G. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood pressure Blood-brain barrier Brain Cell Count Cerebrovascular Disorders - etiology Cerebrovascular Disorders - metabolism Collagen Collagen Type IV - metabolism Collisions Digitization Disease Models, Animal Edema Immunohistochemistry Male Medical sciences Microcirculation - metabolism Microcirculation - pathology Microtubule-Associated Proteins - metabolism Neurology Proteins Rats Rats, Wistar Sinus Thrombosis, Intracranial - complications Sinus Thrombosis, Intracranial - metabolism Sinuses Statistics, Nonparametric Stroke Thrombosis Vascular diseases and vascular malformations of the nervous system Veins & arteries Venous Thrombosis - complications Venous Thrombosis - metabolism
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Zusammenfassung:	We evaluated effects of thrombosis of the superior sagittal sinus, its bridging and cortical veins (SVT) on the cerebral microvasculature in rats. Cryosections of brains ( n=7) were examined for venous infarction and microvascular basal lamina damage 3 h after SVT by immunohistochemical staining of microtubule-associated protein 2 and collagen type IV. Microvessels in the infarctions showed a decrease in the number (23.5+/-6.1%, P
ISSN:	0001-6322 1432-0533
DOI:	10.1007/s00401-003-0755-5