Responses of cultured adult monkey trigeminal ganglion neurons to capsaicin

THE sensitivity of adult primate (Macaca mulatta) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19nA) upon drug application...

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Veröffentlicht in:	Neuroreport 1993-04, Vol.4 (4), p.460-460
Hauptverfasser:	Ingram, Susan L, Martenson, Melissa E, Baumann, Thomas K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Capsaicin - pharmacology Cells, Cultured Female Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Macaca mulatta Male Neurons - drug effects Trigeminal Ganglion - cytology Trigeminal Ganglion - drug effects Vertebrates: nervous system and sense organs
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Zusammenfassung:	THE sensitivity of adult primate (Macaca mulatta) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19nA) upon drug application measured at — 60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-199304000-00032