Dose-dependent effect of alpha-tocopherol on activity of xenobiotic metabolizing enzymes in rat liver

Oral treatment with alpha-tocopherol for 4 days dose-dependently increased the content of cytochrome P450 (CYP), catalytic activities of CYP1A1, CYP1A2, CYP2B1, CYP2C, and activity of NADPH-cytochrome-P450 reductase in the liver of male rats, but did not change activity of glutathione S-transferase....

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2003-07, Vol.136 (1), p.38-41
Hauptverfasser:	Sidorova, Yu A, Ivanova, E V, Grishanova, A Yu, Lyakhovich, V V
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - metabolism alpha-Tocopherol - pharmacology Animals Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP2B1 - metabolism Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Glutathione Transferase - metabolism Liver - drug effects Liver - metabolism Male Microsomes, Liver - drug effects NADPH-Ferrihemoprotein Reductase - metabolism Rats Rats, Wistar Xenobiotics - pharmacology
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Zusammenfassung:	Oral treatment with alpha-tocopherol for 4 days dose-dependently increased the content of cytochrome P450 (CYP), catalytic activities of CYP1A1, CYP1A2, CYP2B1, CYP2C, and activity of NADPH-cytochrome-P450 reductase in the liver of male rats, but did not change activity of glutathione S-transferase. These results suggest that alpha-tocopherol induced the enzymes of phase I of xenobiotic metabolism, including CYP1 and CYP2 families involved in the metabolism of drugs and procarcinogenes.
ISSN:	0007-4888
DOI:	10.1023/A:1026080611490