Fluorescent diagnostics of human gastric cancer and sodium fluorescein accumulation in experimental gastric cancer in rats

Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (Fl). Eighty-five percent of gastric cancers showed positive fluorescence. The Fl distributio...

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Veröffentlicht in:	Cancer letters 1993-04, Vol.69 (2), p.117-121
Hauptverfasser:	Braginskaja, O.V., Lazarev, V.V., Polsachev, V.I., Rubin, L.B., Stoskii, V.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals diagnostics of cancer Female Fluorescein Fluoresceins - metabolism fluorescent dyes Gastritis - diagnosis human gastric cancer induced tumors Neoplasms, Experimental - metabolism Rats Spectrometry, Fluorescence Stomach Diseases - diagnosis Stomach Neoplasms - diagnosis Ulcer - diagnosis
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Beschreibung
Zusammenfassung:	Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (Fl). Eighty-five percent of gastric cancers showed positive fluorescence. The Fl distribution in the stomach of the rat with induced gastric cancer was examined. In all cases the level of Fl fluorescence in the tumor was higher than in the adjacent normal tissues of the stomach. Thus, all the obtained results confirm the selective accumulation of Fl in tumors of the stomach.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/0304-3835(93)90163-4