Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)

Leishmania donovani promastigote lines resistant to hexadecylphosphocholine (HePC, miltefosine) at 2.5, 5.0, 10.0, 20.0 and 40.0 μM were developed in vitro by continuous step-wise drug pressure. The 40 μM line was 15 times more resistant to HePC than the wild-type clone and showed cross-resistance t...

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Veröffentlicht in:	International journal of antimicrobial agents 2003-10, Vol.22 (4), p.380-387
Hauptverfasser:	Seifert, Karin, Matu, Sangeeta, Javier Pérez-Victoria, F., Castanys, Santiago, Gamarro, Francisco, Croft, Simon L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences DNA, Protozoan - genetics Drug Resistance Gene Amplification Hexadecylphosphocholine Leishmania Leishmania donovani - drug effects Leishmania donovani - genetics Medical sciences Miltefosine Pharmacology. Drug treatments Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology
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