Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery

Objective: Platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptors represent the final common pathway for aggregation. GPIIb/IIIa inhibition with antibodies or RGD peptides prevents arterial thrombosis. The present study examined the ability of SC-49992 (SC), a GPIIb/IIIa receptor antagonist, to preve...

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Veröffentlicht in:Cardiovascular research 1993-03, Vol.27 (3), p.500-507
Hauptverfasser: Rote, William E, Werns, Steven W, Davis, James H, Feigen, Larry P, Kilgore, Kenneth S, Lucchesi, Benedict R
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Sprache:eng
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Zusammenfassung:Objective: Platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptors represent the final common pathway for aggregation. GPIIb/IIIa inhibition with antibodies or RGD peptides prevents arterial thrombosis. The present study examined the ability of SC-49992 (SC), a GPIIb/IIIa receptor antagonist, to prevent thrombosis in a canine model of carotid artery thrombosis. Methods: Both carotid arteries of anaesthetised dogs were instrumented with Doppler probes. A 300 μA current was applied to the intimal surface of the right carotid artery via an intraluminal electrode; time to occlusive thrombus formation was noted. SC (30 and 60 μg·kg−1·min−1 intravenously) or saline was infused for 240 min. The procedure for thrombus formation was repeated after 60 min of drug infusion for the left carotid artery. Results: SC did not alter heart rate or blood pressure. Frequency of occlusive thrombus formation was reduced or prevented in a dose dependent manner (control=100%, n=12; SC 30 μg=50%, n=6; SC 60 μg=0%, n=6; p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/27.3.500