Tacrine inhibits ventricular fibrillation induced by ischaemia and reperfusion and widens QT interval in rat

Objective: Tacrine was used as a tool to examine whether block of inward rectifying potassium current (IK1) represents a mechanism for suppression of arrhythmias induced by ischaemia and reperfusion. Methods: Isolated rat hearts (n=10-l2 per group) were subjected to 30 min left regional ischaemia fo...

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Veröffentlicht in:	Cardiovascular research 1993-03, Vol.27 (3), p.453-458
Hauptverfasser:	Rees, Siân A, Curtis, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiarythmic agents Biological and medical sciences Cardiac Pacing, Artificial Cardiovascular system Coronary Circulation - drug effects Dose-Response Relationship, Drug Electrocardiography Heart Rate - drug effects IK1 Male Medical sciences myocardial ischaemia Myocardial Ischemia - complications Myocardial Reperfusion Pharmacology. Drug treatments Rats Rats, Wistar reperfusion tacrine Tacrine - pharmacology ventricular fibrillation Ventricular Fibrillation - prevention & control
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Beschreibung
Zusammenfassung:	Objective: Tacrine was used as a tool to examine whether block of inward rectifying potassium current (IK1) represents a mechanism for suppression of arrhythmias induced by ischaemia and reperfusion. Methods: Isolated rat hearts (n=10-l2 per group) were subjected to 30 min left regional ischaemia followed by reperfusion with and without tacrine. Rat heart was used to permit delayed rectifier (IK) block to be disregarded in interpretation of results (rat ventricle is deficient in functional IK). Results: The incidence of ischaemia-induced ventricular fibrillation was reduced from 70% to 42%, 17% (p
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/27.3.453