Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was eff...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-05, Vol.260 (5112), p.1320-1322
Hauptverfasser:	Howcroft, T. Kevin, Strebel, Klaus, Martin, Malcolm A., Singer, Dinah S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Cell lines Exons Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Products, tat - genetics Gene Products, tat - physiology Genes, MHC Class I - genetics Genes, tat Genetic aspects HeLa Cells HIV HIV (Viruses) HIV 1 HIV-1 - genetics human immunodeficiency virus 1 Humans MHC class I genes Microbiology Promoter regions Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Repression rev genes T lymphocytes tat Gene Products, Human Immunodeficiency Virus Transfection Virology Virus-induced immunosuppression Viruses
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