Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was eff...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1993-05, Vol.260 (5112), p.1320-1322
Hauptverfasser: Howcroft, T. Kevin, Strebel, Klaus, Martin, Malcolm A., Singer, Dinah S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was effected by the HIV-1 Tat protein derived from a spliced viral transcript (two-exon Tat). These studies define an activity for two-exon Tat distinct from that of one-exon Tat and suggest a mechanism whereby HIV-1-infected cells might be able to avoid immune surveillance, allowing the virus to persist in the infected host.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8493575