Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was eff...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1993-05, Vol.260 (5112), p.1320-1322
Hauptverfasser: Howcroft, T. Kevin, Strebel, Klaus, Martin, Malcolm A., Singer, Dinah S.
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container_issue 5112
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container_title Science (American Association for the Advancement of Science)
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creator Howcroft, T. Kevin
Strebel, Klaus
Martin, Malcolm A.
Singer, Dinah S.
description Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was effected by the HIV-1 Tat protein derived from a spliced viral transcript (two-exon Tat). These studies define an activity for two-exon Tat distinct from that of one-exon Tat and suggest a mechanism whereby HIV-1-infected cells might be able to avoid immune surveillance, allowing the virus to persist in the infected host.
doi_str_mv 10.1126/science.8493575
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Kevin</creatorcontrib><creatorcontrib>Strebel, Klaus</creatorcontrib><creatorcontrib>Martin, Malcolm A.</creatorcontrib><creatorcontrib>Singer, Dinah S.</creatorcontrib><title>Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Major histocompatibility complex (MHC) class I molecules are the major receptors for viral peptides and serve as targets for specific cytotoxic T lymphocytes. Human immunodeficiency virus-type 1 (HIV-1) specifically decreased activity of an MHC class I gene promoter up to 12-fold. Repression was effected by the HIV-1 Tat protein derived from a spliced viral transcript (two-exon Tat). 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source MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science
subjects AIDS/HIV
Biological and medical sciences
Cell lines
Exons
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Products, tat - genetics
Gene Products, tat - physiology
Genes, MHC Class I - genetics
Genes, tat
Genetic aspects
HeLa Cells
HIV
HIV (Viruses)
HIV 1
HIV-1 - genetics
human immunodeficiency virus 1
Humans
MHC class I genes
Microbiology
Promoter regions
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Repression
rev genes
T lymphocytes
tat Gene Products, Human Immunodeficiency Virus
Transfection
Virology
Virus-induced immunosuppression
Viruses
title Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV
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