C-terminal pro-ghrelin peptides are present in the human circulation

We provide the first evidence for the existence in human plasma of peptides derived from the 66 carboxyl-terminal amino acids of pro-ghrelin (C-ghrelin). C-ghrelin immunoreactivity in plasma was higher than ghrelin, and did not significantly correlate with body mass index in normal health. In patien...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-10, Vol.310 (2), p.567-573
Hauptverfasser:	Pemberton, Chris, Wimalasena, Prasangi, Yandle, Tim, Soule, Steven, Richards, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino Acid Sequence Animals Chromatography, High Pressure Liquid Female Ghrelin Heart Failure - blood Humans Male Molecular form Molecular Sequence Data Motilin - blood Motilin - chemistry Myocardial Infarction - blood Peptide Fragments - blood Peptide Fragments - chemistry Peptide Hormones - blood Peptide Hormones - chemistry Pro-ghrelin Protein processing Radioimmunoassay
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Zusammenfassung:	We provide the first evidence for the existence in human plasma of peptides derived from the 66 carboxyl-terminal amino acids of pro-ghrelin (C-ghrelin). C-ghrelin immunoreactivity in plasma was higher than ghrelin, and did not significantly correlate with body mass index in normal health. In patients with myocardial infarction, plasma levels of both ghrelin and C-ghrelin were significantly decreased (∼30%, P
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2003.09.045