Genes for the Dimerization Cofactor of Hepatocyte Nuclear Factor-1α (DCOH) Are on Human and Murine Chromosomes 10

Hepatocyte nuclear factor-1α (HNF-1α; gene symbol, TCF1) forms dimers with itself as well as with HNF-1β and regulates the expression of several liver-specific genes. Recently, a dimerization cofactor of hepatocyte nuclear factor-1α, called DCOH, has been identified. Here, we report the chromosomal...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1993-04, Vol.16 (1), p.292-295
Hauptverfasser:	Milatovich, Athena, Mendel, Dirk B., Crabtree, Gerald R., Francke, Uta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Southern Chromosome Mapping Chromosomes, Human, Pair 10 Classical genetics, quantitative genetics, hybrids Cricetinae DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells Hydro-Lyases - genetics Mice Nucleic Acid Hybridization Species Specificity Transcription Factors - genetics
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Beschreibung
Zusammenfassung:	Hepatocyte nuclear factor-1α (HNF-1α; gene symbol, TCF1) forms dimers with itself as well as with HNF-1β and regulates the expression of several liver-specific genes. Recently, a dimerization cofactor of hepatocyte nuclear factor-1α, called DCOH, has been identified. Here, we report the chromosomal localization of the genes for this cofactor to chromosomes 10 in both humans and mice by Southern blot analyses of somatic cell hybrids.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1993.1182