Plasma fentanyl levels in infants undergoing extracorporeal membrane oxygenation

Plasma fentanyl levels in infants undergoing extracorporeal membrane oxygenation

Plasma levels of fentanyl were analyzed in 12 infants undergoing extracorporeal membrane oxygenation who received a fentanyl bolus (5 to 10 μg/kg) followed by infusion at 1 to 6.3 μg/kg/hr. Fentanyl levels, averaging 11 samples/infant, were measured by radioimmunoassay (mean 19.7 ± 35.7 ng/ml; n = 1...

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Veröffentlicht in:The Journal of thoracic and cardiovascular surgery 1993-05, Vol.105 (5), p.885-891
Hauptverfasser: Leuschen, M. Patricia, Willett, Lynne D., Hoie, Eric B., Bolam, David L., Bussey, Mary E., Goodrich, Paul D., Zach, Terence L., Nelson, Robert M.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesia
Extracorporeal Membrane Oxygenation
Female
Fentanyl - administration & dosage
Fentanyl - blood
Hernia, Diaphragmatic - mortality
Hernias, Diaphragmatic, Congenital
Humans
Infant
Infant, Newborn
Infusions, Intravenous
Lorazepam - therapeutic use
Male
Prospective Studies
Radioimmunoassay
Time Factors
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Zusammenfassung:Plasma levels of fentanyl were analyzed in 12 infants undergoing extracorporeal membrane oxygenation who received a fentanyl bolus (5 to 10 μg/kg) followed by infusion at 1 to 6.3 μg/kg/hr. Fentanyl levels, averaging 11 samples/infant, were measured by radioimmunoassay (mean 19.7 ± 35.7 ng/ml; n = 140). Eight of the infants, all with a primary diagnosis other than congenital diaphragmatic hernia, survived with relatively short (
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(19)34161-3