Palladium-Catalyzed C−H Functionalization of Heteroarenes with Aryl Bromides and Chlorides

Palladium-Catalyzed C−H Functionalization of Heteroarenes with Aryl Bromides and Chlorides

Palladium-catalyzed C−H arylation of electron-enriched heteroarenes with aryl bromides and aryl chlorides proceeds in the presence of LiO-t-Bu as a base. The reaction allows one-pot synthesis of differently substituted 2,5-diarylthiazole with the same catalyst system by switching the solvent and the...

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Veröffentlicht in:Journal of organic chemistry 2010-10, Vol.75 (20), p.6998-7001
Hauptverfasser: Tamba, Shunsuke, Okubo, Youhei, Tanaka, Shota, Monguchi, Daiki, Mori, Atsunori
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Hydrocarbons, Brominated - chemistry
Hydrocarbons, Chlorinated - chemistry
Molecular Structure
Organic chemistry
Organometallic Compounds - chemistry
Palladium - chemistry
Preparations and properties
Stereoisomerism
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Thiazoles - chemical synthesis
Thiazoles - chemistry
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Zusammenfassung:Palladium-catalyzed C−H arylation of electron-enriched heteroarenes with aryl bromides and aryl chlorides proceeds in the presence of LiO-t-Bu as a base. The reaction allows one-pot synthesis of differently substituted 2,5-diarylthiazole with the same catalyst system by switching the solvent and the amount of base.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo101433g