Regulation of fibrinogen production by microRNAs

Elevated levels of fibrinogen are associated with increased risk of cardiovascular disease, whereas low fibrinogen can lead to a bleeding disorder. We investigated whether microRNAs (miRNAs), known to act as post-transcriptional regulators of gene expression, regulate fibrinogen production. Using tr...

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Veröffentlicht in:	Blood 2010-10, Vol.116 (14), p.2608-2615
Hauptverfasser:	Fort, Alexandre, Borel, Christelle, Migliavacca, Eugenia, Antonarakis, Stylianos E., Fish, Richard J., Neerman-Arbez, Marguerite
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Biological and medical sciences Cell Line Cell Line, Tumor Fibrinogen - genetics Fibrinogen - metabolism Gene Expression Regulation Genes, Reporter Hematologic and hematopoietic diseases Humans Medical sciences MicroRNAs - genetics
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