Comparative Study of Skin Permeation Profiles between Brand and Generic Tulobuterol Patches

Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β2-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaired, we compared the skin penetration profiles of the brand and generic patches using a skin barrier-impaired rat model. Skin penetration was significantly (p