Lupane triterpenes and derivatives with antiviral activity

Betulin and betulinic acid have been modified at the C-3 and C-28 positions and the antiviral activity of derivatives has been evaluated in vitro. It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simp...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-10, Vol.13 (20), p.3549-3552
Hauptverfasser:	Baltina, L A, Flekhter, O B, Nigmatullina, L R, Boreko, E I, Pavlova, N I, Nikolaeva, S N, Savinova, O V, Tolstikov, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology Microbial Sensitivity Tests Triterpenes - chemistry Triterpenes - pharmacology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Betulin and betulinic acid have been modified at the C-3 and C-28 positions and the antiviral activity of derivatives has been evaluated in vitro. It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simplex type 1 viruses.
ISSN:	0960-894X
DOI:	10.1016/S0960-894X(03)00714-5