3D MRI of the in vivo vestibulo-cochlea labyrinth during Gd-DTPA-BMA uptake

The morphology, time-course and volume of the in vivo uptake of the T1 contrast agent gadolinium (Gd) in the perilymphatic vestibulo-cochlea labyrinth, including the utricle, saccule, semicircular canals and scalae of the guinea pig inner ear were analyzed as Fourier transform signal intensity enhan...

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Veröffentlicht in:	Neuroreport 2003-09, Vol.14 (13), p.1707-1712
Hauptverfasser:	Allen Counter, S, Zou, Jing, Bjelke, Börje, Klason, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Cochlea - metabolism Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Ear, Inner - metabolism Female Fistula - metabolism Fourier Analysis Fundamental and applied biological sciences. Psychology Gadolinium - metabolism Gadolinium DTPA Guinea Pigs Imaging, Three-Dimensional Magnetic Resonance Imaging - methods Male Perilymph - metabolism Time Factors Vertebrates: nervous system and sense organs Vestibule, Labyrinth - metabolism
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Zusammenfassung:	The morphology, time-course and volume of the in vivo uptake of the T1 contrast agent gadolinium (Gd) in the perilymphatic vestibulo-cochlea labyrinth, including the utricle, saccule, semicircular canals and scalae of the guinea pig inner ear were analyzed as Fourier transform signal intensity enhancement levels by 3D MRI at 4.7 T. The uptake of Gd as a function of time in the perilymphatic space of the vestibular labyrinth was shown by ANOVA and PLSD post hoc tests to be significantly less (p
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200309150-00010