Lessons in how to hold a fork

What prevents the replisome complex from moving along the DNA or breaking down when the replication fork stalls or encounters a DNA lesion? A recent paper describes how checkpoint proteins, Mrc1 and Tof1 couple the replisome to DNA synthesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2003-10, Vol.10 (10), p.778-779
Hauptverfasser:	Zegerman, Philip, Diffley, John F X
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DNA Replication - genetics DNA Replication - physiology DNA-Binding Proteins Genes, cdc Intracellular Signaling Peptides and Proteins Life Sciences Membrane Biology Mutation news-and-views Protein Structure Protein-Serine-Threonine Kinases Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
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Beschreibung
Zusammenfassung:	What prevents the replisome complex from moving along the DNA or breaking down when the replication fork stalls or encounters a DNA lesion? A recent paper describes how checkpoint proteins, Mrc1 and Tof1 couple the replisome to DNA synthesis.
ISSN:	1072-8368 1545-9993 2331-365X 1545-9985
DOI:	10.1038/nsb1003-778