Bombesin acts in the brain to decrease gastric vagal efferent discharge in rats

Bombesin acts in the brain to decrease gastric vagal efferent discharge in rats

The central nervous system action of bombesin to influence basal gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Bombesin (62, 620, and 6200 pmol) injected intracisternally (IC) decreased GVED to 78 ± 10%, 50 ± 4%, and 43 ± 3% of preinjection levels, respectiv...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1993-03, Vol.14 (2), p.339-343
Hauptverfasser: Yoshida-Yoneda, Eriko, Wei, Jen Yu, Taché, Yvette
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Bombesin
Bombesin - administration & dosage
Bombesin - pharmacology
Bombesin monoclonal antibody
Brain - drug effects
Brain - physiology
Efferent Pathways - drug effects
Efferent Pathways - physiology
Electrophysiology
Fundamental and applied biological sciences. Psychology
Gastric vagus
Injections, Intravenous
Injections, Intraventricular
Intracisternal
Male
Rats
Rats, Sprague-Dawley
Stomach
Vagal efferent activity
Vagus Nerve - drug effects
Vagus Nerve - physiology
Vertebrates: digestive system
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Zusammenfassung:The central nervous system action of bombesin to influence basal gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Bombesin (62, 620, and 6200 pmol) injected intracisternally (IC) decreased GVED to 78 ± 10%, 50 ± 4%, and 43 ± 3% of preinjection levels, respectively. Bombesin (620 pmol) injected IV also reduced GVED to 36 ± 6%. Pretreatment with bombesin monoclonal antibody 2A11 completely prevented the decrease in GVED induced by bombesin (620 pmol) given IV but not IC. These data indicate that both IC and IV injections of bombesin decrease basal GVED, and that the inhibitory effect of IC injection represents a central nervous system-mediated action.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(93)90050-Q