Titanocene(III)-Promoted Reformatsky Additions

Titanocene(III)-Promoted Reformatsky Additions

A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are als...

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Veröffentlicht in:Organic letters 2003-10, Vol.5 (20), p.3615-3617
Hauptverfasser: Parrish, J. D, Shelton, Daniel R, Little, R. Daniel
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035269c