Mitogenic Response of Osteoblast Cells to Prostate-Specific Antigen Suggests an Activation of Latent TGF-β and a Proteolytic Modulation of Cell Adhesion Receptors

Mitogenic Response of Osteoblast Cells to Prostate-Specific Antigen Suggests an Activation of Latent TGF-β and a Proteolytic Modulation of Cell Adhesion Receptors

During studies of mitogens in prostate, PSA quantities as low as 2.5 ng/mL caused cultured osteoblast cells to proliferate beyond controls ( p=

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Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 1993-04, Vol.192 (2), p.940-947
Hauptverfasser: Killian, C.S., Corral, D.A., Kawinski, E., Constantine, R.I.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cell Adhesion
Cell Division
Dissemination
Hydrolysis
Medical sciences
Osteoblasts - cytology
Osteoblasts - metabolism
Osteosarcoma
Plasminogen Activators - pharmacology
Prostate-Specific Antigen - pharmacology
Rats
Transforming Growth Factor beta - metabolism
Tumor cell
Tumor Cells, Cultured
Tumors
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Beschreibung
Zusammenfassung:During studies of mitogens in prostate, PSA quantities as low as 2.5 ng/mL caused cultured osteoblast cells to proliferate beyond controls ( p=
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1993.1506